The expression of ARSD was significantly associated with molecular subtype (p < 0.001), clinical stage (p = 0.004), histological stage (p < 0.001), ER (p < 0.001), PR (p = 0.004), Ki67 (p = 0.003), and TopIIα (p = 0.013), respectively, but it was in no correlation with age, tumor size, LN metastasis, Her2, p53, VEGF. The gene discussed is ESR1; the disease is neoplasm.