Similar results were obtained with BAX/BAK DKO human colon cancer HCT116 cells (Supplementary Fig. S1B), which are more resistant than WT cells in response to mitoxantrone, cisplatin, and oxaliplatin, similarly susceptible to CytD and only partially resistant to Noco, paclitaxel, docetaxel, and vinblastine (Supplementary Fig. S1C). Here, BAX is linked to colonic neoplasm.