TNBC patients were identified from TCGA13, CPTAC14, the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC)15, and from the MET50016 using genomic data guided by the expression distribution of clinically defined ER, PR, and HER2 tumors (Supplementary Fig. 1a and “Methods”). This evidence concerns the gene ESR1 and breast carcinoma.