After similar adjustment for potential explanatory variables (i.e., age, sex, breath rate, heart rate, SaO2, systolic blood pressure, alanine aminotransferase, eGFR, COPD, CAD, and DM), serum TNF-α acted as an independent risk factor in this model for the mortality among patients with COVID-19 (1.047 [1.014–1.082]; p = 0.006). This evidence concerns the gene TNF and chronic obstructive pulmonary disease.