A number of studies reveal the roles of ErbB4, EGFR, ErbB2 activation in necrosis or apoptosis of macrophages, cancer cells, and a variety of cell types (Högnason et al., 2001; Tikhomirov and Carpenter, 2004; Jackson and Ceresa, 2017; Schumacher et al., 2017). This evidence concerns the gene ERBB4 and cancer.