In cachexic subjects, sustaining catabolism and inflammation will accelerate the production of TNF-ɑ, IL-6 and IL-1 to block lipoprotein lipase [49] and the L-carnitine-induced fatty acid transfer system, leading to hypertriglyceridemia and hypercholesterolemia [21, 22]. This evidence concerns the gene IL6 and familial hypercholesterolemia.