Additionally, IL-23 production was enhanced in the presence of increased IL-1 receptors.86 The secretion of IL-23 decreased when inflammasome activation was inhibited in the presence of extracellular K+ ions.86 In the case of murine model of IBD, dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid-induced colitis NLRP3 inflammasome is activated. The gene discussed is NLRP3; the disease is colitis.