Activation of the P2Y6 receptor (a G-protein coupled receptor) in Caco-2 cells, which releases UDP (uridine diphosphate) as a danger signal, has been linked to the induction of CXCL8/IL-8, a potent neutrophil chemoattractant following the exposure to TcdA and TcdB.97 Treatment with the P2Y6-receptor-antagonist MRS2578 abrogated the toxin-induced CXCL8/IL-8 release and inflammation in mice.97 These data open new avenues for treatment of severe inflammation in CDI mediated colitis. Here, CXCL8 is linked to clostridium difficile infection.