IL10 and colitis: Abrogation of cellulose production reduced the AIEC-mediated colitis in IL10-/- KO mice, which are highly sensitive to inflammation.41 Altering the availability of iron modulates the community structure in wild type and in IL10-/- KO mice.42 Depletion of the iron in the lumen was linked with dysbiotic states, inducing iron scavenging by Enterobacteriaceae pathobionts.42