Notable exceptions to this include a subclade of low-heterozygosity strains (clade 13, Candida africana) that show decreased virulence in animal models of infection and may be restricted to genital tract infections (42, 79) and hyperfilamentous nrg1 mutants that have been repeatedly recovered from the lungs of cystic fibrosis patients (80). The gene discussed is NRG1; the disease is cystic fibrosis.