However, Ecker et al. observed a threshold effect of improved overall survival associated with the upper quartile of HAPLN1 expression in melanoma [21], while Ivanova et al. found high expression of HAPLN1 was negatively correlated with time to progression and overall survival in malignant pleural mesothelioma [22]. The gene discussed is HAPLN1; the disease is malignant pleural mesothelioma.