Nude mouse studies indicated that the tumour volume in MKN45/CAFs-sh HAPLN1 group was smaller than that in MKN45/CAFs group (Figs. 5B, s3B, P < 0.001), indicating that HAPLN1 knockdown in CAFs can inhibit MKN45 tumourigenesis in vivo. The gene discussed is HAPLN1; the disease is neoplasm.