MPO and Cowden disease: The role of neutrophils in IBD pathogenesis currently remains controversial, as inhibition of neutrophil activity has been shown to have both beneficial and deleterious effects during intestinal inflammation.5,6,35 Recent studies with animal models of IBD using specific inhibitors of neutrophil-MPO-mediated oxidative damage have inferred protection against disease progression.36,37 Therefore, our data demonstrating that NETosis is evident in human CD specimens indicate neutrophil-MPO may play a role in the pathogenesis of CD.