Moreover, the progressive reduction in PN AP firing frequency we report, which positively correlates with the development of ataxia in the AtmR35X/R35X; Aptx−/− mice, is reported in a large number of ataxic mouse models, including SCAs 1, 2, 3, 5, 6, and 13 as well as a few episodic forms (see review Cook et al., 2021). This evidence concerns the gene APTX and cerebellar ataxia.