ALKBH3 and cancer: On the other hand, ALKBH3 is often overexpressed in different cancers and inhibition of ALKBH2 and ALKBH3 can sensitize cancer cells to alkylating chemotherapy (Choi et al., 2011; Koike et al., 2012; Tasaki et al., 2011; Wang et al., 2015; Wu et al., 2011).