This is of particular importance since both ALKBH2 and ALKBH3 have been proposed as tumor suppressors, being silenced in various tumors, including gastric and breast cancer (Fedeles et al., 2015; Gao et al., 2011; Knijnenburg et al., 2018; Stefansson et al., 2017). The gene discussed is ALKBH2; the disease is breast carcinoma.