It was found that in the cells with upregulated HIPK1, the cell proliferation, migration, invasion, and N-cadherin, pAkt, Perk, and Vimentin expression levels were memorably elevated, while apoptosis and E-cadherin expression were clearly decreased (Figure 5b-g), suggesting that HIPK1 overexpression promotes the growth and metastasis of LC cells. The gene discussed is HIPK1; the disease is laryngotracheoesophageal cleft.