the levels of neutrophilic granulocyte% (N%), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), creatinine (Cr), blood urea nitrogen (BUN), blood potassium (K+), phosphorus and depression scores were significantly increased, while the levels of total cholesterol (TC), hemoglobin (HB) and albumin were significantly decreased in the patients with ESRD (with or without depression) compared with the healthy controls. The gene discussed is ALB; the disease is major depressive disorder.