The decoration of the bisecting GlcNAcin human brain glycans may be of particular significance because GnT-III,which produces the bisecting structures, shows altered expressionlevels in Alzheimer’s disease patients53,54 and other diseases.55 Therefore, interest in this element and otherglyco-features experiences a renaissance.22,56,57. The gene discussed is MGAT3; the disease is early-onset autosomal dominant Alzheimer disease.