TP53 and breast cancer: On the other hand, novel synergistic combination mechanisms can also be identified (Figure 7J); for example, the combination of SET And MYND Domain Containing 2 (SMYD2) and PRKCA (Protein Kinase C Alpha), in which SMYD2 is related to transcriptional regulation by TP53 and promotes breast cancer,[47] whereas PRKCA participates in the regulation of organelle organization and involves several cancers.[48, 49]