Because reduced insulin/IGF1 signalling leads to lifespan extension in worms (Kenyon et al., 1993) and hypomorphic mutants of the insulin/IGF1-like receptor daf-2 show increased healthspan (Podshivalova et al., 2017) including a delay in the onset of sarcopenia (Kashyap et al., 2012), we decided to use this model. The gene discussed is INS; the disease is sarcopenia.