This mentioned nanoformulation (bovLfn-Fe3O4 nano-constructs) achieved considerably encouraging tumor rejection in triple-positive (EpCAM, CD133, CD44) colon cancer xenograft mouse models inducing higher survival rates in comparison with non-targeted nano-constructs which demonstrates the importance of nano-constructs functionalization with the anti-NCL and anti-EpCAM aptamers [128]. This evidence concerns the gene EPCAM and malignant colon neoplasm.