NCL aptamer-siRNA (AS1411-siRNA) chimeras specific for SLUG (aptNCL-SLUGsiR) and NRP1 (aptNCL-NRP1siR) can be used for specific tumor invasion and angiogenesis suppression in only metastatic tumor cells without blocking the signaling pathways of cells that are under physiologic conditions [96]. Here, NRP1 is linked to neoplasm.