Considering that IDH1 wild-type GBMs are developed from IDH1 wild-type grade II or III astrocytomas or as de novo, which are originally different from IDH1-mutant astrocytomas and oligodendrogliomas or 1p19q codeleted oligodendrogliomas [18]. The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).