Decreased STOX1 expression was significantly associated with advanced WHO grades (Grade IV) (P < 0.0001), more aggressive pathological subtypes (GBM) (P < 0.0001), older age (≥45 years) (P < 0.0001), and less IDH1 mutation (P < 0.0001) (Tables 1 and 2). Here, IDH1 is linked to glioblastoma.