IL13 and neoplasm: M2a, named wound-healing macrophages, can be activated by IL-4 or interleukin 13 (IL-13); M2b can be activated upon combined exposure to immune complexes (IC) and Toll-like receptor (TLR) agonists or by IL-1R agonists; M2c, called inactivated macrophages, can be activated by transforming growth factor-β (TGF-β) and cortex hormones; and M2d, known as tumor-associated macrophages (TAMs), can be activated by costimulation with TLR ligands and A2 adenosine receptor (A2R) agonists or by IL-6 [27, 28].