Interestingly, Ragusa et al. detected the miRNA transcriptome in colorectal cancer with the treatment of MAPK/extracellular signal-regulated kinase (ERK) inhibitors and found that hsa-miR-663b was upregulated in three cell lines and induced downregulation of cyclin D2 (CCND2) [67]. The gene discussed is CCND2; the disease is colorectal cancer.