circ_0002346 overexpression restrained cell glycolytic metabolism, and the introduction of miR-582-3p mimics largely rescued the glycolytic rate of NSCLC cells (Figures 4(i)–4(k)), verified by the increased rates of glucose consumption and lactate production and the protein levels of HK2 and PKM2. The gene discussed is PKM; the disease is non-small cell lung carcinoma.