HIF1A and gastric cancer: Hypoxia-inducible factor-1 (HIF-1) is the core factor in regulating the hypoxia stress response and mediating the physiological behavior of hypoxic cells, HIF-1α also inhibits the activation of β-catenin that is mediated by hARD1, then downregulates expression of Wnt in gastric cancer cells or osteoblasts (44).