SCN5A and epilepsy: These reports about metal poisoning eliciting a BrS ECG pattern are also consistent with the fact that metals, such as zinc and copper, can act as endogenous regulators of sodium, potassium, and calcium channels, including NaV1.5, the sodium channel most implicated in BrS, through mechanisms that could be important not only for the heart, but also for diseases such as Alzheimer's disease and epilepsy (120).