Some of these genes, CREM, PTPN1, HRH1 in addition to PRCP, HSPB8, and STARD13 appeared to be involved in hypertrophy, pressure of the LV, altered heart ventricle contractility, and vascular endothelial cell function, representing the main dysregulated cardiovascular disease related functions found in RZ (Figure 2E, lower panel). This evidence concerns the gene CREM and cardiovascular disorder.