SFRP2 and Myocardial fibrosis: Previous studies have shown divergent roles of sFRP2 in myocardial fibrosis (16–18), hypertrophy (19), angiogenesis (20), cardiac cell death (21), and regeneration (22, 23) via bi-directional regulation of the canonical Wnt pathway, activation of non-canonical Wnt pathway or modulation of other signaling pathways (24).