Meanwhile, the haplotypes of CYP17A1 rs1004467A-rs11191548T, CYP17A1 rs1004467G-rs11191548C, and ATP2B1 rs1401982G-rs17249754A had a protective effect for hypertension, whereas the haplotype of ATP2B1 rs1401982A-rs17249754G revealed an increased susceptibility of disease (p < 0.001). This evidence concerns the gene CYP17A1 and Hypertension.