Therefore, the purpose of this research was to test the association of ATP2B1 (rs1401982 and rs17249754) and CYP17A1 (rs1004467 and rs11191548) SNPs, and their haplotypes, G × G and G × E interactions, with hypertension in the Maonan population. The gene discussed is CYP17A1; the disease is Hypertension.