The miR-1246-enriched exosomes derived from TP53 mutants cancer cells are uptaken by macrophages and trigger them to reprogram into a tumor supportive and anti-inflammatory state via TGF-β activation (Cooks et al., 2018), and hypoxic glioma-derived exosomal miR-1246 induces M2 phenotype by targeting TERF2IP to activate the STAT3 signaling pathway and inhibit the NF-κB signaling pathway (Qian et al., 2020), subsequently promoting tumor proliferation, migration and invasion. Here, STAT3 is linked to neoplasm.