Pathways and molecules involved in polarizing TAM are diverse in different tumors, including: IL-4 and IL-13, eosinophils (Eos) and basophils (Bas); cytokines and metabolites from cancer cells; antibodies (Ab) from B cells and immune complex; stromal cell-derived factors (IL-1, LT) (Mantovani et al., 2017). This evidence concerns the gene IL1B and cancer.