Macrophages incubated with HCC cell-derived exosomes containing lower level of circ_00074854 showed notably reduced level of IL-10 compared to those incubated with HCC cell-derived exosomes, indicating that exosomes with low circ_00074854 level could suppress macrophage M2 polarization, which in turn suppressing migration and invasion of HCC cells both in vitro and in vivo (Wang et al., 2021). Here, IL10 is linked to hepatocellular carcinoma.