Colorectal cancers with high C3 gene level exhibited a hyperactivation of several pathways including pathways in cancer (Figure 7G), TGF-BETA signaling (Figure 7H), JAK-STAT signaling (Figure 7I), MAPK signaling (Figure 7J), VEGF signaling (Figure 7K), and WNT signaling (Figure 7L). The gene discussed is SOAT1; the disease is colorectal cancer.