The results of univariate Cox regression analysis demonstrated that some parameters, including SYDE1 expression, age, WHO grade, primary/recurrent/secondary (PRS) type, histology, radiotherapy, chemotherapy, IDH mutation, and 1p/19q codeletion status, were independent risk factors for the prognosis prediction in glioma patients based on the CGGA mRNA-array_325. This evidence concerns the gene SYDE1 and central nervous system cancer.