The top-ranking genes were related to the TRIP10, NR2F6, ACTN4, SBNO2, and TGFB1L1 genes (p < 0.05), and a link between ACTN4 and TGFB1L1 expression and tumorigenesis was shown in glioma samples (Ji et al., 2019). This evidence concerns the gene ACTN4 and central nervous system cancer.