Notably, the expression of SYDE1 in older patients aged ≥45 years was higher than that in patients aged <45 years in the CGGA mRNA-array_301 (p < 0.05, Supplementary Figure S1A), CGGA mRNA-array_325 (p < 0.05, Supplementary Figure S1B), GSE4271 (p < 0.05, Supplementary Figure S1C), and TCGA_glioma datasets (p < 0.05, Figure 2A). The gene discussed is SYDE1; the disease is central nervous system cancer.