IDH1 and central nervous system cancer: There are many well-studied pathogenic genes and regulators of gliomas, including IDH1/2, 1p/19q codeletion, integrin β1 (ITGB1) and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E mutation (Chintala et al., 1996; Schiffman et al., 2010; Yip et al., 2012).