MLXIPL and fatty liver disease: Regulating metabolic nuclear receptors, such as the sterol regulatory element-binding protein-1c (Srebp-1c), carbohydrate response element-binding protein (ChREBP), and peroxisome proliferator-activated receptor γ (PPAR-γ) prevents hepatic steatosis caused by a high-fat diet (HFD), indicating that uncontrolled de novo lipogenesis contributes to the development of NAFLD (4–6).