In addition, the activation of AHR/CD36 pathway promotes hepatic steatosis in mice (36), while inhibiting the activity of AHR and altering the expression levels of CYP1B1, PPARα, and SCD-1 that attenuate the diet-induced obesity and hepatic steatosis in mice (37). This evidence concerns the gene CYP1B1 and obesity due to melanocortin 4 receptor deficiency.