Proof of concept of the efficacy of gene replacement in RLBP1-related RP came from a study conducted on a mouse model of the disease, in which self-complementary AAV8 vector carrying the gene for human RLBP1 under control of a short RLBP1 promoter (scAAV8-pRLBP1-hRLBP1, or CPK850) was delivered via SRI, resulting in an improved electroretinographic response (189). This evidence concerns the gene RLBP1 and retinitis pigmentosa 1.