As an important group of cytoplasmic RNA sensors, the RIG-I-like receptors (RLRs) are composed of three proteins (RIG-I, MDA5, and LGP2) that are similar in their structure and function, and all of them are able to recognize viral nucleic acid signatures during the viral infections (Rehwinkel and e Sousa, 2010; Bruns and Horvath, 2014). This evidence concerns the gene IFIH1 and viral infectious disease.