Lu Y. et al. (2018) found that DANCR expression was induced by MYC, a common oncogene, which resulted in the reduction of p21, a protein required for cell cycle progression. Enzalutamide, a kind of AR (androgen receptor) inhibitor, was used to treat PCa. However, in some cases, it caused side effects such as PCa metastasis (Lin et al., 2013). DANCR knockdown limited the enzalutamide-induced metastasis. Mechanically, DNACR could inhibit TIMP2/3 expression by binding to EZH2 (Jia et al., 2016). Here, TIMP2 is linked to posterior cortical atrophy.