In hepatitis-associated neoplastic transformation, NF-κB activation enhances TNF-α, which in turn enhances NF-κB-dependent anti-apoptotic gene expression in a feed-forward loop (Pikarsky et al., 2004), and IKK2 is required for epithelial growth during colitis-associated cancer (Greten et al., 2004). This evidence concerns the gene NFKB1 and Hepatitis.