SLC7A11 and GPX4 were highly expressed in CRC cell lines and CRC tissues compared with paired normal tissues, and downregulation of SLC7A11 by talaroconvolutin or downregulation of GPX4 by apatinib or inactivation of GPX4 by resibufogenin could induce ferroptosis of CRC cells (Yagublu et al., 2011; Ma et al., 2015; Xia et al., 2020; Shen et al., 2021; Tian et al., 2021). The gene discussed is GPX4; the disease is colorectal carcinoma.