Very importantly, both SLC7A11 and GPX4 were overexpressed in CRC including colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) and upregulated in pan-kidney cohort including kidney renal clear cell carcinoma (KIRC), KICH, and kidney renal papillary cell carcinoma (KIRP) comparing with adjacent normal tissues. This evidence concerns the gene GPX4 and colorectal carcinoma.