We observed that high expression levels of GPX4 and AIFM2 were significantly associated with tumor purity in ESCA (R = 0.25, p = 6.93e-04; R = 0.279, p = 1.43e-04) and in HNSC, respectively (R = 0.223, p = 5.37e-07; R = 0.205, p = 4.41e-06; Figure 5). The gene discussed is GPX4; the disease is neoplasm.