Very importantly, both SLC7A11 and GPX4 were overexpressed in CRC including colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) and upregulated in pan-kidney cohort including kidney renal clear cell carcinoma (KIRC), KICH, and kidney renal papillary cell carcinoma (KIRP) comparing with adjacent normal tissues. The gene discussed is GPX4; the disease is colon adenocarcinoma.