ATM and obesity due to melanocortin 4 receptor deficiency: Moreover, as evidence suggests that ATMs are highly plastic according to their surrounding environment, and obesity is strongly associated with the number, derivation, and functional changes of ATMs (Lumeng et al., 2008; Xu et al., 2013), regulation of ATM subgroups toward mitochondrial uptake subgroups is a promising therapeutic approach for obesity and related metabolic syndromes.