KLF4 has been widely reported as an oncogene in multiple cancer types (Rowland and Peeper, 2006; Hu et al., 2015; Hsieh et al., 2017; Murgai et al., 2017), including lung cancer (Yu et al., 2016), ovarian cancer (Zhang et al., 2019), esophageal squamous cell cancer (Tetreault et al., 2010), gastric cancer (Li et al., 2012), colorectal cancer (Li et al., 2011; Gamper et al., 2012), and leukemia (Faber et al., 2013; Li et al., 2015; Seipel et al., 2016; Park et al., 2019). Here, KLF4 is linked to esophageal squamous cell carcinoma.