TP53 and osteosarcoma: Zhang et al. (2019) reported that LINC01116 might remarkably accelerate the proliferation, migration, and invasion of osteosarcoma cells, but substantially precludes cell apoptosis. These results corroborated that LINC01116 directly interacted with EZH2 to mediate PTEN and p53. Thus, EZH2 knockdown reverses the LINC01116 functional effect on osteosarcoma cells (Zhang et al., 2019). Zhang et al. (2018) silenced LINC01116, inhibiting the viability of osteosarcoma cells and promoting cell apoptosis.