In melanoma cells, Wnt5a promotes the release of immunoregulatory and proangiogenic factors from exosomes (Ekström et al., 2014), while melanoma cell-derived exosomes can regulate lymphatic endothelial cells and myeloid-derived suppressor cells (MDSCs) to enhance the tolerance capacity of lymph gland to tumors, finally achieving immune evasion (Hood, 2016). The gene discussed is WNT5A; the disease is melanoma.