PORCN and cancer: Although several studies have suggested that acylation mediated by PORCN is necessary for Wnt secretion (Kadowaki et al., 1996; Barrott et al., 2011; Biechele et al., 2011), the latest findings in several cancer cells lines and a specific T cell seem to contradict that (Richards et al., 2014; Rao et al., 2019).