EPHA2 and cancer: eHSP90 binding to LRP1 activates ERK, AKT, and NF-κB pathways and induces ephrin type-A receptor 2 (EPHA2) recruitment and activation, promoting lamellipodia formation and cancer cell motility and invasion (Chen et al., 2010; Gopal et al., 2011; Tsen et al., 2013; Nagaraju et al., 2015).