Similar effects have been described in vitro and in cancer preclinical models for the monoclonal antibody against eHSP90 (4C5), able to disrupt the eCDC37/eHSP90/HER2 or EGFR complex (Stellas et al., 2007, 2010; El Hamidieh et al., 2012). The gene discussed is ERBB2; the disease is cancer.