MAP3K7 and fatty liver disease: Other molecules, including the E3 ligase tripartite motif 8 (TRIM8) (Yan et al., 2017) and tumor necrosis factor receptor-associated factor 3 (TRAF3) (Wang et al., 2016) can promote liver steatosis and insulin resistance by activating the phosphorylation of TAK1 and its downstream JNK/p38 and NF-κB signaling.