A comprehensive proteomic analysis of CAFs-associated outer vesicles revealed that membrane-linked protein Annexin A6 effectively enhanced drug resistance in gastric cancer cells by activating β1 integrin-focal adhesion kinase (FAK)-YAP and inhibition of FAK or YAP may be a novel strategy for overcoming gastric cancer drug resistance (Uchihara et al., 2020). The gene discussed is PTK2; the disease is gastric cancer.