Interestingly, IFN-γ is a broad-spectrum PD-L1 inducer, capable of elevating PD-L1 expression in a variety of tumor and immune cells (Sun et al., 2018) and measuring IFN-γ expression levels in the microenvironment allows for a rough determination of PD-L1 abundance (Chen et al., 2018). The gene discussed is CD274; the disease is neoplasm.