Besides, fork-head box C1 (Foxc1) (Lay et al., 2016; Wang L. et al., 2016), LIM homeobox 2 (Lhx2) (Folgueras et al., 2013), collagen type XVII alpha 1 (Col17a1) (Matsumura et al., 2016) are all crucial to aging properties of HFs. This evidence concerns the gene LHX2 and Hand-foot syndrome.