ALK and lung adenocarcinoma: In several different cancers, TPR is present through fusion genes, which is formed by coiled-coil motif in TPR with some kinase partner genes such as MET (gastric cancer) (Soman et al., 1991), NTRK1 (thyroid carcinoma) (Greco et al., 1992), FGFR1 (myeloproliferative syndromes) (Li et al., 2012), and ALK (lung adenocarcinoma) (Choi et al., 2014).