Zhang X. et al. (2020) reported that miltirone, a phenanthraquinone derivative isolated from Radix Salviae Miltiorrhizae, could inhibit hepatocellular carcinoma cells proliferation and induce the proteolysis of GSDME and cleavage of caspase 3. Furthermore, gasdermin also attaches importance to gastric, lung, skin, and esophageal squamous cancer (Xia et al., 2019). Yang et al. (2020) have reported that NLRP3, caspase-1, and GSDMD were upregulated in EC, and activation in pyroptosis could lead to an anti-tumor effect. The gene discussed is GSDMD; the disease is neoplasm.