The expression of ALDOB is upregulated in liver metastatic tumor cells, and the upregulation of glucose metabolism provides energy for metastatic tumor cells, resists apoptosis and autophagy, inhibits oxidative stress, and maintains tumor cell proliferation under severe hypoxia, while a low-fructose diet significantly reduces the growth of liver metastatic cells (Chae et al., 2016; Bu et al., 2018; Leong, 2018). The gene discussed is ALDOB; the disease is neoplasm.