1) Compare the SLE group (Fifteen patients were randomly selected from the Traditional treatment group and the Sirolimus group and combined as the pre-treatment SLE group) before treatment with the normal children, the expression of LC3 protein in peripheral blood lymphocytes increased, with statistical significance ([0.3686 ± 0.0832] vs. [0.5175 ± 0.0721], t = −5.428, P = 0.0003); the expression of P62 protein in peripheral blood lymphocytes decreased, with statistical significance ([0.6005 ± 0.089] vs. [0.4965 ± 0.0731], t = 3.456, P = 0.001). This evidence concerns the gene SQSTM1 and systemic lupus erythematosus.