Although HOXB13 overexpression promotes prostate cancer metastasis by downregulating intracellular zinc and upregulating NF-kappaB signaling pathways, HOXB13 consumption promotes proliferation of PC-3 and LNCaP cells by controlling G1/S and G2/M checkpoints (16, 60, 67, 138, 141). The gene discussed is HOXB13; the disease is Familial prostate cancer.